Superior Council of Scientific Investigations

Jaume Pérez Sánchez (IP1)

Institution: CSIC
Category: Research Professor
E-Mail: jaime.perez.sanchez@csic.es

Josep Calduch Giner (IP2)

Institution: CSIC

Category: Senior Scientist

E-Mail: j.calduch@csic.es

Álvaro Belenguer Ferrando

Institution: CSIC

Category: Senior Scientist

E-Mail: a.belenguer@csic.es

Federico Moroni

Institution: CSIC

Category: Postdoc Contracted

E-Mail: federico.moroni@csic.es

Fernando Naya Catalá

Institution: CSIC

Category: PhD student in Biotechnology

E-Mail: fernando.naya@iats.csic.es

Ricardo Domingo Bretón

Institution: CSIC

Category: PhD student in Biotechnology

E-Mail: ricardo.domingo@csic.es

Paul George Holhorea

Institution: CSIC

Category: Bachelor of Marine Sciences

E-Mail: paul.holhorea@csic.es

Mª Angeles González Albaladejo

Institution: CSIC

Category: Tecnic laboratory

María Hernández Marín

Institution: CSIC

Category: ThinkInAzul Manager

E-Mail: gestion.thinkinazul@csic.es

Jaime Nàcher Mestre

Institution: EDEM
Category: Undergraduate Professor
E-Mail: jnacher@edem.es

Carlos Llorens

Institution: Biotechvana
Category: CEO
E-Mail: carlos.llorens@biotechvana.com

Ahmed Hafez

Institution: Biotechvana
Category: Doctor of Biomedicine
E-Mail: ahmed.hafez@biotechvana.com

Aya Allah Ali Elsayed

Institution: Biotechvana
Category: Industrial PhD Student
E-Mail: ayoya.ali@biotechvana.com

Beatriz Soriano Salvador

Institution: Biotechvana

Category: Industrial PhD Student
E-Mail: beatriz.soriano@biotechvana.com

José María Sempere Luna

Institution: Polytechnic University of Valencia

Category: Associate Professor
E-Mail: jsempere@dsic.upv.es

Tasks responsible for WP3:

• Task 3.1.1: Biosensors.
• Task 3.1.4: Computational analysis and omic integration tools.
• Task 3.1.5: Integrated use of farmed fish welfare assessment platforms.
• Task 3.2.1: New sea bream feed formulations

WP3 participant tasks:

• Task 3.1.3: Monitoring the fatty acid profile.
• Task 3.2.3: Lipid metabolism.
• Task 3.3.1: Valorize discards and by-products from the fishing and meat industries
• Task 3.3.3: Inclusion of functionalized ingredients in feed
• Task 6.2.2: Environmental and socioeconomic interactions: prevention, contingency and mitigation.

Naya-Català, F., Piazzon, MC, Torrecillas, S., Toxqui-Rodríguez, S., Calduch-Giner, JA, Fontanillas, R., Sitjà-Bobadilla, A., Montero, D., & Pérez-Sánchez, J. (2022b). Genetics and Nutrition Drive the Gut Microbiota Succession and Host-Transcriptome Interactions through the Gilthead Sea Bream (spars aurata) Production Cycle. Biology, 11(12), 1744.

Naya-Català, F., Pereira, GDV, Piazzon, MC, Fernandes, AFC, Calduch-Giner, JA, Sitjà-Bobadilla, A., Conceição, LE, & Pérez-Sánchez, J. (2021). Cross-Talk Between Intestinal Microbiota and Host Gene Expression in Gilthead Sea Bream (spars aurata) Juveniles: Insights in Fish Feeds for Increased Circularity and Resource Utilization. Frontiers in Physiology, 12

Piazzon, MC, Naya-Català, F., Perera, E., Palenzuela, O., Sitjà-Bobadilla, A., & Pérez-Sánchez, J. (2020). Genetic selection for growth drives differences in intestinal microbiota composition and parasite disease resistance in gilthead sea bream. microbiome, 8(1)

Pérez-Sánchez, J., Naya-Català, F., Soriano, B., Piazzon, MC, Hafez, AI, Gabaldón, T., Llorens, C., Sitjà-Bobadilla, A., & Calduch-Giner, JA (2019). Genome Sequencing and Transcriptome Analysis Reveal Recent Species-Specific Gene Duplications in the Plastic Gilthead Sea Bream (spars aurata). Frontiers in Marine Science, 6.

Pérez-Sánchez, J., Simó-Mirabet, P., Naya-Català, F., Perera, E., Bermejo-Nogales, A., Benedito-Palos, L., & Calduch-Giner, JA (2018). Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes. Frontiers in Endocrinology, 9.

Moreno-Mariscal, C., Moroni, F., Pérez-Sánchez, J., Mora, L., & Toldrá, F. (2025). Optimization of Sequential Enzymatic Hydrolysis in Porcine Blood and the Influence on Peptide Profile and Bioactivity of Prepared Hydrolysates. International Journal of Molecular Sciences, 26(8), 3583. https://doi.org/10.3390/ijms26083583

Nácher-Mestre, J., Cano, DL, Habib, KA, Branchadell, CM, & Pérez-Sánchez, J. (2025). Curbing petrochemical lubricants by plant-based chemicals: A reliable opportunity to align with sustainable development goals. Lubricants (Basel, Switzerland), 13(2), 71. https://doi.org/10.3390/lubricants13020071

Moroni, F., Naya-Català, F., Hafez, AI, Domingo-Bretón, R., Soriano, B., Llorens, C., & Pérez-Sánchez, J. (2025). Beyond microbial variability: Disclosing the functional redundancy of the core gut Microbiota of farmed gilthead sea bream from a Bayesian network perspective. microorganisms, 13(1), 198. https://doi.org/10.3390/microorganisms13010198

Domingo-Bretón, R., Cools, S., Moroni, F., Belenguer, A., Calduch-Giner, JA, Croes, E., Holhorea, PG, Naya-Català, F., Boon, H., & Pérez-Sánchez, J. (2025). Intestinal microbiota shifts by dietary intervention during extreme heat summer episodes in farmed gilthead sea bream (Sparus aurata). Aquaculture Reports, 40(102566), 102566. https://doi.org/10.1016/j.aqrep.2024.102566

Domingo-Bretón, R., Moroni, F., Toxqui-Rodríguez, S., Belenguer, Á., Piazzon, MC, Pérez-Sánchez, J., & Naya-Català, F. (2024). Moving beyond oxford nanopore standard procedures: New insights from water and multiple fish microbiomes. International Journal of Molecular Sciences, 25(23), 12603. https://doi.org/10.3390/ijms252312603

Holhorea, PG, Naya-Català, F., Domingo-Bretón, R., Moroni, F., Belenguer, Á., Calduch-Giner, J. À., & Pérez-Sánchez, J. (2024). Behavioral monitoring underlines habituation to repeated stressor stimuli in farmed gilthead sea bream (spars aurata) reared at a high density stocking. Biology, 13(11), 879. https://doi.org/10.3390/biology13110879

França, TS, González-López, WA, Sanchez, MP, Ferrão, L., Fernández-García, F., Borges,LP, Belenguer, A., Holhorea, PG, Calduch-Giner, JC, Felip, A., Gómez, A., Pérez-Sánchez, J., Streit, DP, Asturiano, JF (2024) Successful Cryopreservation in biodegradable containers of sperm from aquaculture Mediterranean fishes. Theriogenology, 216, 53-61. https://doi.org/10.1016/j.theriogenology.2023.12.016.

Belenguer, Á., Naya-Català, F., Calduch-Giner, J. À., & Pérez-Sánchez, J. (2024). Exploring multifunctional markers of biological age in farmed gilthead sea bream (spars aurata): A transcriptomic and epigenetic interplay for an improved fish welfare assessment approach. International Journal of Molecular Sciences, 25(18), 9836. https://doi.org/10.3390/ijms25189836

Simó-Mirabet, P., Naya-Català, F., Calduch-Giner, JA, & Pérez-Sánchez, J. (2024). The expansion of Sirtuin gene family in gilthead sea bream (spars aurata)—phylogenetic, syntenic, and functional insights across the vertebrate/fish lineage. International Journal of Molecular Sciences, 25(11), 6273.https://doi.org/10.3390/ijms25116273

Naya-Català, F., Torrecillas, S., Piazzon, MC, Sarih, S., Calduch-Giner, J. À., Fontanillas, R., Hostins, B., Sitjà‐Bobadilla, A., Acosta, F., Pérez‐Sánchez, J., & Montero, D. (2024). Can the genetic background modulate the effects of feed additives? Answers from gut microbiome and transcriptome interactions in farmed gilthead sea bream (spars aurata) fed with a mix of phytogenics, organic acids or probiotics. Aquaculture, 740770. 

Naya-Català, F., Belenguer, Á., Montero, D., Torrecillas, S., Soriano, B., Calduch-Giner, J. À., Lloréns, C., Fontanillas, R., Sarih, S., Zamorano, MJ, Izquierdo, M., & Pérez‐Sánchez, J. (2023). Broodstock nutritional programming differentially affects the hepatic transcriptome and genome-wide DNA methylome of farmed gilthead sea bream (spars aurata) depending on genetic background. BMC Genomics, 24(1). https://doi.org/10.1186/s12864-023-09759-7

Holhorea, PG, Naya-Català, F., Belenguer, Á., Calduch-Giner, J. À., & Pérez‐Sánchez, J. (2023). Understanding how high stocking densities and concurrent limited oxygen availability drive social cohesion and adaptive features in regulatory growth, antioxidant defense and lipid metabolism In farmed gilthead sea bream (spars aurata). Frontiers in Physiology, 14.

Soriano, B., Hafez, AI, Naya-Català, F., Moroni, F., Moldovan, RA, Toxqui-Rodríguez, S., Piazzon, MC, Arnau, V., Llorens, C., & Pérez-Sánchez, J. (2023). SAMBA: Structure-Learning of Aquaculture Microbiomes using a Bayesian approach. Genes, 14(8), 1650.

Hafez, AI, Soriano, B., Elsayed, AA, Futami, R., Ceprian, R., Ramos-Ruiz, R., Martinez, G., Roig, FJA, Torres-Font, MA, Naya-Català, F., Calduch-Giner, JA, Trilla-Fuertes, L., Gámez-Pozo, A., Arnau, V., Sempere, JM, Pérez-Sánchez, J., Gabaldon, T., & Llorens, C. (2023). Client Applications and Server-Side Docker for Management of RNASeq and/or VariantSeq Workflows and Pipelines of the GPRO Suite. Genes, 14(2), 267.

Calduch-Giner, JA, Holhorea, PG, Ferrer, M., Naya-Català, F., Rosell-Moll, E., García, CM, Prunet, P., Espmark, Å. MO, Leguen, I., Kolarevic, J., Vega, A., Kerneis, T., Goardon, L., Afonso, JC, & Pérez-Sánchez, J. (2022). Reviewing the Impact and Prospects of Activity and Ventilation Rate Bio-Loggers for Tracking Welfare and Fish-Environment Interactions in Salmonids and Mediterranean Farmed Fish. Frontiers in Marine Science, 9.

Holhorea, PG, Felip, A., Calduch-Giner, JA, Afonso, JC, & Pérez-Sánchez, J. (2023). Use of male-to-female sex reversal as a welfare scoring system in the protandrous farmed gilthead sea bream (spars aurata). Frontiers in veterinary science, 9.